Prolastin (Talecris Biotherapeutics C formerly Bayer)

Prolastin (Talecris Biotherapeutics C formerly Bayer) - General Information

Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.

Pharmacology of Prolastin (Talecris Biotherapeutics C formerly Bayer)

Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema.

Prolastin (Talecris Biotherapeutics C formerly Bayer) for patients

Prolastin (Talecris Biotherapeutics C formerly Bayer) Interactions

Prolastin (Talecris Biotherapeutics C formerly Bayer) Contraindications

Zemaira^™ is contraindicated in individuals with a known hypersensitivity to any of its components. Zemaira^™ is also contraindicated in individuals with a history of anaphylaxis or severe systemic response to A₁-PI products. Individuals with selective IgA deficiencies who have known antibodies against IgA (anti-IgA antibodies) should not receive Zemaira^™, since these patients may experience severe reactions, including anaphylaxis, to IgA that may be present in Zemaira^™.

Additional information about Prolastin (Talecris Biotherapeutics C formerly Bayer)

Prolastin (Talecris Biotherapeutics C formerly Bayer) Indication: For treatment of panacinar emphysema
Mechanism Of Action: Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). It primarily inhibits the action of the serine protease called elastase (also plasmin and thrombin). The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Alpha-1-proteinase inhibitor
Synonyms: Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin precursor; Alpha 1-antitrypsin
Drug Category: Enzyme Replacement Agents
Drug Type: Biotech; Approved

Other Brand Names containing Alpha-1-proteinase inhibitor: Aralast (Baxter); Prolastin (Talecris Biotherapeutics C formerly Bayer);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Prolastin (Talecris Biotherapeutics C formerly Bayer): Injection, powder, lyophilized, for solution Intravenous
Chemical IUPAC Name: Alpha-1-proteinase inhibitor
Chemical Formula: C2001H3130N514O601S10
Alpha-1-proteinase inhibitor on Wikipedia: https://en.wikipedia.org/wiki/Alpha_1-antitrypsin
Organisms Affected: Humans and other mammals